Lewy Body Disease?
Saturday, June 13, 2009
The son and daughter of the patient bring her to the movement disorder
specialist with a provisional diagnosis of Lewy Body Disease. Frederic
Lewy gave his name to the bits of protein he found in the cytoplasm of
cells throughout the brain in the early 1900s. The illness is
characterized by dementia, fluctuations in cognition- attention,
alertness and thinking ability from day to day, and Parkinsonism.
Lewy
Body Disease might have made a more simple patient case. The actual
patient had a history of high blood pressure, neurosurgery to correct a
potentially fatal aneurysm, which Wikipedia defines as a "blood-filled
dilation (balloon-like bulge) of a blood vessel caused by disease or
weakening of the vessel wall." Neuroradiology discovered a tumor on her
cerebellum while performing an MRI to ascertain the state of the
aneurysm. The children of the patient noted she had trouble finding the
appropriate words for objects, following surgery, an observation that
coincides with an aneurysm on the left side of the brain, the language
center. After surgery, patients routinely receive Dilantin,
prophylactically, to avoid seizures caused by minute scarring of
cortical tissue. The patient never took the medication and suffered a
seizure in the presence of her 85-year-old husband. The children also
reported an incident in which the patient, "went crazy" after her
medications were changed. Though the craziness subsided with new drugs,
she still suffered from significant mental changes, for example she
could not report her correct age.
With all her troubles, the
children of the patient commented she was in good health and rarely
needs medical attention. On physical examination, the specialist noted
tremor in her left hand and arm with less involvement on the right
side. He felt some rigidity, more on the left than right, when the
patient was distracted by performing a concurrent activity- in this
case; she tapped her palm on her thigh. Parkinsonism also appeared as
decreasing amplitude in repeated finger to thumb tapping. Of note also
were brisk reflexes and upward going toes- a Babinski sign indicative
of brain disease, specifically damage to the corticospinal tracts. The
patient felt incapable of independent walking, so the physician gauged
her standing and balance skills. Without support, she could stand with
feet touching, though the left side of her body twitched noticeably.
With her eyes closed, she stood considerably less still and when
jostled she lost balance quickly.
The patient complained most
about the tremor on the left side of her body. This symptom is what the
specialist addressed, by recommending a medication that successfully
quells tremor that would not interact with her other medications. To
complicate matters a bit more, the doctor learned the patient refuses
to take any medications given to her by her husband, with whom she
lives. The patient fears he is trying to kill her. For this reason, an
independent person must visit the home bringing the necessary drugs.
When
the dilemma unfolded, the physician commented Medicare pays for home
health to dispense medications. He wrote a prescription for this
service, as well as for physical therapy. The patient left the office
on the arm of her son, and was clearly unstable with tremor rocking the
left side of her torso.
Hints of PD
Friday, June 05, 2009
She just wanted to be told she didn't have Parkinson's disease.
Unfortunately, the doctor couldn't dispel her worries. She did have
tremor; what sort of tremor is questionable. Sometimes causes are
unclear, time helps clarify issues, though few people can ever pinpoint
the cause of Parkinson's disease. Those who can identify a true cause
of the illness may subscribe it to having a genetic mutation, though
familial patterns of Parkinson's disease are quite rare.
The
patient suffered from temporal arteritis, inflammation of the temporal
artery. The harrowing condition has symptoms like tenderness of the
scalp and hair, pain in the jaw and when chewing, and loss or
blurriness of vision. Doctors prescribe oral steroids to bring
inflammation under control, because vision can be lost and never
regained if flow through the ophthalmic artery gets disrupted and the
patient has no secondary means of blood circulation to the eye. For
some reason, women are three times more likely to suffer from this
problem than men. Rheumatoid arthritis or systemic lupus erythematosus
may coincide with the ailment; the patient lived with the former.
Upon
examination, the doctor noticed brisker reflexes on the right side as
well as slight rigidity when engaged in a simultaneous task. Though the
patient reported a tremor that could shake wine from her glass, the
tremor during examination was mild and fine. Might arteritis be the
cause of her physical symptoms? Rigidity may result from inflammation
in the brain, but the spouse reported tremor was worsening. With the
course of steroids, inflammation should resolve, causing rigidity to
improve.
Worsening tremor is unlikely to result from
inflammatory processes in the brain. If the patient suffers from a
Parkinsonian syndrome then tremor should gradually worsen and involve
both sides of the body at rest, or other symptoms should appear. With
the request to return to clinic in six months to a year, the physician
prescribed Selegiline with the hope of forestalling and diminishing a
possible loss of dopaminergic neurons.