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2010 (24)
Illness from the Islands
Thursday, January 21, 2010

A psychiatrist in the Virgin Islands treated the patient for fourteen years. When the movement disorder specialist looked at the list of medications, he was impressed and satisfied with the regimen. Only after the patient had fallen, spent a week in the hospital then been transferred to a rehabilitation facility where he spent most of his time in bed, did his health appear to be threatened. A family member commented he couldn't lift himself up from a lying position, when he first arrived in the States. With family care and physical therapy, he appeared at the clinic using a walker.


Seeking to know more of the patient's history, the doctor asked about the first symptoms of illness. Tremor began in the right hand and after two years or so, spread to the left hand. The doctor commented two types of PD are generally recognized, the tremor dominant type and the rigid, akinetic kind. He commented the patient is lucky to have the tremor dominant type, though the illness is more apparent, it also progresses more slowly. On physical examination, the physician noted the patient was quite stiff in the neck and torso, but an increased level of Sinemet would relieve some of this. Happy the patient was having physical therapy, he recommended therapy continue until Medicare refused to cover the cost.


In addition to gradually increasing the level of Sinemet, for which he drew out a chart for the family, the doctor suggested the patient begin using the medication, Ditropan at night. The drug increases the bladder's holding capacity, so one can sleep an entire night without the urge to urinate. On the cautious side, when given with other drugs, specifically Artane, it may increase a patient's risk of acquiring a bladder infection. The physician warned the patient and family to be aware of this, and cut the patient's dose of Artane to avoid possible problems. An adequate dose of Seroquel at night would ensure the patient falls asleep and remains so until the following morning. He stressed the patient avoid daytime napping and make an effort to exercise daily.


The doctor, not feeling rushed, as he allocates an hour for new patients, digressed a bit on medications. Artane, he stated, is one of the oldest drugs given to those with PD and is quite effective for tremor. To its detriment, the medication can interfere with short-term memory in patients over the age of 60, worsens constipation and interferes with bladder function. Sinemet, so named for sin emesis- Latin for without vomit, has three potential side effects- nausea; that's why it's best to take the drug with food, it can cause drops in blood pressure, and it may bring on hallucinations, especially in patients not sleeping well at night.


The physician urged the patient continue taking Mirapex and amantadine as he had previous been instructed. After the change in dosage of Sinemet, which would take approximately a month to fully accomplish, they could tweek the doses of other medications. In addition, he advised the patient to avoid protein- rich foods throughout the day, eating instead a diet rich in fruit, vegetables, and carbohydrates. Eating foods that lack amino acids enables Sinemet to act effectively and reduce symptoms of illness. At dinner, with the idea the evening will be quiet, spent reading or watching television and not line dancing, the patient should take the daily requirement of protein. The neutral amino acids in protein will interfere with the transport of levodopa from blood to brain, so the patient is apt to feel slower and not have the same response to medications, as when taken without protein during the day. To manage the illness effectively, it seems best to plan ahead of time what foods to eat at a particular meal. The doctor stressed he would like the patient to return in three months time, but that if problems arose to call his assistant, and he provided them a card with the appropriate office number.

Unvoluntary Movements
Sunday, January 17, 2010
Somewhere between the extremes of voluntary willed and involuntary, uncontrollable movement lies the gray area of unvoluntary movement. People with tics are thought to suffer from unvoluntary movements because they are able to consciously suppress urges to perform the motion.  While restraining themselves, the desire to perform the action builds until they are unable to contain themselves and they release a flurry of tics.

A patient appeared in the movement disorder clinic, referred by his neurologist because the patient's case was beyond his level of expertise. The patient reported an overwhelming need to move his legs or change position- something one would commonly hear from a person suffering from restless legs syndrome.  Indeed, the patient had taken Mirapex, a drug prescribed for that disorder. Unfortunately, the medication did little his need to move, so that the odd movements he felt compelled to perform embarrassed him, and causing him to seek a doctor's opinion. Movement disorders come in patterns. The patterns are based on physiological derangement of cells, in the case of Parkinson's disease movements eventually arise when the population of dopamine producing neurons has diminished remarkably within the substantia nigra.

The patient's movements were similar to those in Monty Python's Ministry of Silly Walks, there were random and odd. The patient reported he didn't know why he performed them, other than to calm a restless need he felt within his body. The loved one of the patient, who accompanied him to the appointment, stated he also moves oddly while sleeping.

The patient's medical history included a clipped aneurysm; the bulging blood vessel had bled irregularly and given the patient tremendously painful headaches. He had been advised to have surgery, which he had done. He also suffers from diabetes, had undergone rotator cuff surgery and spinal surgery, in which a surgeon fused several levels of vertebra in his spine.

Diabetes invariably brings vascular disease, as the endothelial cells lining the smallest vessels in the brain and body degenerate because they are unable to utilize sugar. Neuropathies occur as a consequence of inadequate function of the blood vessels serving nerves and may present with decreased sensation in the feet and fingers. Diabetes may have contributed to the sensory changes in his limbs and could contribute in part to restless leg syndrome. But the extent of the unusual movements appeared much beyond the typical movements of the limbs seen in restless leg syndrome.

On physical examination, the clinician found no rigidity in the muscles of the arms. Reflexes were symmetrical and normal. The clinician documented the patient's responses to fine motor testing as the medical student led the examination. Discussing his thoughts with the patient and significant other, the physician suggested the patient increase his level of antidepressant and add a small dose of the generic medication primozide, or the brand name equivalent Orap,  given commonly to those suffering with tics.  He also requested the patient obtain records of the neurosurgery performed nearly ten years ago, to ascertain if an MRI of the brain can be done. The practitioner requested the patient return in three months time, when a further discussion including past records can occur, and after gauging whether the current medications prove helpful.